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How does the 'living computer' with 800,000 human neurons capable of playing video games work?
A technological demonstration released this month caught the attention of the innovation sector by showing something that, at first glance, seems like science fiction: human neurons grown in a laboratory playing video games. The experiment was presented by the Australian startup Cortical Labs, which released a video of its CL1 biological device running the classic game Doom.
A clump of human brain cells can play the classic computer game Doom. While its performance is not up to par with humans, experts say it brings biological computers a step closer to useful real-world applications, like controlling robot arms.
In 2021, the Australian company Cortical Labs used its neuron-powered computer chips to play Pong. The chips consisted of clumps of more than 800,000 living brain cells grown on top of microelectrode arrays that can both send and receive electrical signals. Researchers had to carefully train the chips to control the paddles on either side of the screen.
Now, Cortical Labs has developed an interface that makes it easier to program these chips using the popular programming language Python. An independent developer, Sean Cole, then used Python to teach the chips to play Doom, which he did in around a week.
“Unlike the Pong work that we did a few years ago, which represented years of painstaking scientific effort, this demonstration has been done in a matter of days by someone who previously had relatively little expertise working directly with biology,” says Brett Kagan of Cortical Labs. “It’s this accessibility and this flexibility that makes it truly exciting.”
The neuronal computer chip, which used about a quarter as many neurons as the Pong demonstration, played Doom better than a randomly firing player, but far below the performance of the best human players. However, it learnt much faster than traditional, silicon-based machine learning systems and should be able to improve its performance with newer learning algorithms, says Kagan.
Unlike systems based solely on algorithms, the equipment uses real human brain cells connected to a silicon chip. The neurons receive electrical stimuli corresponding to the game information and respond with signals that are interpreted as actions within the digital environment, such as moving or aiming at enemies.
A computer made of neurons...Presented during the Mobile World Congress 2025 in Barcelona, the CL1 is described by the company as the first commercially viable biological computer. At its core are approximately 800,000 human neurons derived from stem cells reprogrammed from skin and blood samples from adult donors, according to information released by IEEE Spectrum magazine.
These cells grow on an electrode array capable of sending electrical impulses and recording neural tissue responses in real time. In the Doom demonstration, approximately 200,000 neurons received game data converted into electrical signals, processed this information, and produced commands that controlled gameplay.
The public demonstration was not published in a peer-reviewed study. However, the scientific basis of the project has academic precedents: in 2022, researchers affiliated with the company reported in the journal Neuron that similar neuronal cultures were able to learn to play Pong in a few minutes, spontaneously reorganizing themselves.
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Energy efficiency as an advantage...The advance comes amidst the debate about the high energy consumption of artificial intelligence. While large model training centers use enormous amounts of energy, the human brain operates with about 20 watts, comparable to the consumption of an energy-saving light bulb.
According to the company's chief scientist, Brett Kagan, a rack with 30 CL1 units consumes less than one kilowatt in total. The proposal is not to compete directly with GPUs used in artificial intelligence, such as those produced by Nvidia, but to operate in areas where adaptive learning and energy efficiency are more relevant, such as robotics, drug discovery, and modeling neurological diseases.
Convergence between brain and machine...The development occurs in parallel with initiatives that seek to directly integrate the human brain and technology. One of the best known is Neuralink, a company that works on implanting electrodes in the brain for communication with computers.
While projects of this type connect devices to the human brain, the Cortical Labs system follows the reverse path: it takes biological tissue into the machine. Experts point out that, in the future, these two approaches may converge in the creation of hybrid interfaces between biological intelligence and digital computing.
Neurons as a service...In addition to selling the device, whose announced price is around US$35,000 per unit, the company is betting on a remote access model called "wetware as a service". In this system, researchers can use live neuronal cultures hosted in a laboratory for approximately US$300 per week, without needing to maintain their own infrastructure.
Among the startup's investors is In-Q-Tel, a venture capital fund associated with the US intelligence community, indicating a strategic interest in the technology's development.
According to the company, the neuronal cultures used in the system do not present structures associated with consciousness. Even so, researchers acknowledge that the expansion of this type of technology raises ethical and regulatory questions that do not yet have a clear legal framework. For many experts, the discussion about the use of human tissue in commercial computing is only just beginning.
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